Advances in rapid DNA sequencing are helping to solve missing persons cases long gone cold, such as that of 20-year-old Ashley Loring Heavyrunner, who disappeared from Montana’s Blackfeet Reservation in 2017. New testing kits can extract thousands of genetic markers from unidentified human remains, making it easier to link them to missing persons. Because few genetic data are available for Native Americans, Hopi Tribe member Haley Omeasoo, a classmate and distant relative of Heavyrunner, decided to pursue forensic anthropology to help locate missing Indigenous people. As a Ph.D. student at the University of Montana, Omeasoo and her graduate advisor, anthropologist Meradeth Snow, are working with the Blackfeet Tribe to create a DNA database of tribal members that can be compared with unidentified human remains. More than 4,000 sets of human remains are found in the U.S. each year; about a quarter remain unidentified, according to the Bureau of Justice Statistics. Nearly 5,500 reports of missing Indigenous women and girls were filed in 2022 alone. Omeasoo is hopeful Ashley Heavyrunner will be found alive, but she knows that her DNA work could ultimately identify her friend’s remains. If that happens, she hopes it will at least give the family closure.